Don't let calcification be your fate

Orthopedics and Traumatology Specialist Op. Dr. Serhan Yağdı stated that stem cell therapy for cartilage damage is becoming increasingly popular and represents a highly promising treatment option. “The use of mesenchymal stem cells (MSCs) has provided new hope for patients who are candidates for knee replacement,” he said.

Op. Dr. Serhan Yağdı explained that osteoarthritis is a progressive joint disorder characterized by the gradual breakdown of cartilage, which is a smooth, slippery tissue that protects the ends of bones in the knee joint and acts as a cushion. “The most common causes include aging, excessive weight, overuse, genetic predisposition, and female gender. As cartilage wears down, bones may rub against each other, causing pain after movement, morning stiffness, swelling around the knee, reduced joint space, and limited mobility,” he said.

MESENCHYMAL STEM CELL THERAPY

Describing mesenchymal stem cell (MSC) therapy as an advanced regenerative medicine technique for repairing or regenerating damaged tissues, Op. Dr. Yağdı stated, “MSCs are multipotent stem cells capable of differentiating into various cell types, including bone, cartilage, muscle, and fat cells. They are primarily obtained from bone marrow, adipose tissue, or umbilical cord tissue. MSCs can differentiate into different cell types required for tissue repair, regulate the immune system, and reduce inflammation. This can lead to rapid relief from pain and joint complaints. Additionally, they secrete growth factors and cytokines that support tissue repair and healing.”

Addressing the role of stem cells in orthopedic disorders, especially osteoarthritis, Yağdı added: “Mesenchymal stem cells (MSCs) have been proven to be safely used in many orthopedic conditions, including cartilage damage and osteoarthritis, and their high potential has attracted significant interest. In cases of cartilage tissue loss, stem cells obtained from high-tech GMP-equipped laboratories can be easily applied to patients’ damaged areas. Today, for osteoarthritis, cartilage damage, sports injuries, tendon and ligament problems, spinal injuries, and avascular necrosis, the most advanced and effective methods involve combined treatment with exosomes and MSCs. The effectiveness of stem cells can be enhanced by combining them with substances such as PRP (Platelet-Rich Plasma), hyaluronic acid, and collagen peptides. In addition to being easy to administer, minimally painful, highly effective, and reliable, MSC therapy usually involves a single procedure, minimally impacting daily life. Since it is typically applied via injection, it does not require an operating room and can be performed quickly. However, it must be carried out by an experienced and specialized physician who carefully evaluates the patient and determines the most suitable cell type and quantity.”